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2012;2:S162S164

If approved, triple-agonist medications may expand treatment options for individuals who: Have not achieved sufficient results with existing therapies Require more comprehensive metabolic support Have obesity complicated by conditions such as insulin resistance or joint disease For now, retatrutide remains a promising research development rather than a clinical option

Thus, GLP-1 originating from sources in the gut lumen could directly or indirectly activate L-cells

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